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The codeine in acetaminophen and codeine phosphate tablets may raise the frequency of seizures in people with seizure Issues, and will raise the hazard of seizures transpiring in other clinical settings connected with seizures.

If an opioid analgesic is initiated in the patient previously having a benzodiazepine or other CNS depressant, prescribe a reduced Preliminary dose of the opioid analgesic, and titrate according to clinical reaction. Notify patients and caregivers of this possible interaction, teach them about the indications and indications of respiratory depression (like sedation).

Consider prescribing naloxone, based upon the patient’s threat elements for overdose, for example concomitant use of CNS depressants, a historical past of opioid use dysfunction, or prior opioid overdose.

Don't cease making use of codeine abruptly right after very long-term use, otherwise you could have disagreeable withdrawal signs or symptoms. Ask your medical professional ways to securely halt using this medication.

Propulsive peristaltic waves during the colon are lowered, even though tone may be increased to The purpose of spasm, resulting in constipation. Other opioid-induced results may possibly consist of a discount in biliary and pancreatic secretions, spasm of sphincter of Oddi, and transient elevations in serum amylase.

Speak with your healthcare supplier In case the discomfort that you've boosts, if you really feel extra delicate to soreness, or When you've got new soreness immediately after getting acetaminophen and codeine phosphate tablets.

Codeine Codeine is fast absorbed within the gastrointestinal tract. It is rapidly distributed through the intravascular Areas to the different human body tissues, with preferential uptake by parenchymatous organs like the liver, spleen, and kidney.

In people who might be liable to the intracranial results get more info of CO2 retention (e.g., All those with proof of improved intracranial force or brain tumors), acetaminophen and codeine phosphate tablets get more infowebsite may perhaps lessen respiratory travel, as well as resultant CO2 retention here can further maximize intracranial stress.

It's not a complete listing of possible Negative effects. When you see other consequences not listed earlier mentioned, contact your medical professional or pharmacist.

Advise individuals and caregivers not to extend opioid dosage without having initial consulting a clinician. Recommend sufferers to seek professional medical consideration if they encounter symptoms of hyperalgesia, which include worsening ache, increased sensitivity to suffering, or new ache (see WARNINGS; ADVERSE REACTIONS).

Opioids are sought for nonmedical use and are issue to diversion from genuine prescribed use. Look at these risks when prescribing or dispensing acetaminophen and codeine phosphate tablets. Methods to scale back these hazards include things like prescribing the drug during the smallest suitable quantity and advising the affected person on watchful storage with the drug in the study course of procedure and correct disposal of unused drug.

Using acetaminophen and codeine phosphate tablets in clients with acute or extreme bronchial asthma within an unmonitored environment or in the absence of resuscitative machines is contraindicated.

If concomitant use of a CYP3A4 inducer is necessary, follow the affected person for decreased efficacy and signs of opioid withdrawal and think about escalating the acetaminophen and codeine phosphate tablets dosage as necessary. Assess for respiratory melancholy and sedation.

Accidental ingestion of acetaminophen and codeine phosphate tablets, Specially by young children, may end up in respiratory melancholy and Loss of life because of click here an overdose of codeine.